| Round | Type | Opponent | For | Against | Margin | Venue | Date | |
|---|---|---|---|---|---|---|---|---|
| R2 | Home | Williamstown | 14.9 93 | 8.16 64 | 29 | Blacktown Sportspark | 29/03/2025 | Match stats |
| R3 | Home | Sandringham Zebras | 22.19 151 | 6.7 43 | 108 | Blacktown Sportspark | 05/04/2025 | Match stats |
| R4 | Away | Casey Demons | 19.6 120 | 9.13 67 | 53 | Casey Fields | 19/04/2025 | Match stats |
| R5 | Home | Footscray Bulldogs | 17.18 120 | 6.11 47 | 73 | Blacktown Sportspark | 27/04/2025 | Match stats |
| R6 | Away | Sydney Swans | 13.13 91 | 9.11 65 | 26 | SCG | 04/05/2025 | Match stats |
| R7 | Away | Geelong VFL | 16.11 107 | 11.9 75 | 32 | Kardinia Park | 11/05/2025 | Match stats |
| R8 | Away | Collingwood VFL | 5.15 45 | 8.8 56 | -11 | Victoria Park | 17/05/2025 | Match stats |
| R9 | Home | Port Melbourne | 12.12 84 | 16.14 110 | -26 | Albury Oval | 25/05/2025 | Match stats |
| R10 | Home | Richmond VFL | 12.8 80 | 13.14 92 | -12 | GIANTS Stadium | 31/05/2025 | Match stats |
| R11 | Home | Northern Bullants | 23.12 150 | 7.5 47 | 103 | Blacktown Sportspark | 07/06/2025 | Match stats |
| R12 | Away | Brisbane Lions | 11.8 74 | 24.15 159 | -85 | Springfield Central | 15/06/2025 | Match stats |
| R13 | Home | Gold Coast Suns | 15.3 93 | 12.8 80 | 13 | GIANTS Stadium | 21/06/2025 | Match stats |
| R15 | Away | Werribee Tigers | 11.12 78 | 8.11 59 | 19 | Chirnside Park | 05/07/2025 | Match stats |
| R16 | Home | Geelong VFL | 9.11 65 | 18.7 115 | -50 | GIANTS Stadium | 12/07/2025 | Match stats |
| R16 | Home | Geelong VFL | GIANTS Stadium | 12/07/2025 | ||||
| R17 | Away | Essendon VFL | Windy Hill | 18/07/2025 | ||||
| R18 | Home | Sydney Swans | GIANTS Stadium | 25/07/2025 | ||||
| R19 | Away | Footscray Bulldogs | Whitten Oval | 01/08/2025 | ||||
| R21 | Away | Gold Coast Suns | Carrara Stadium | 16/08/2025 |